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Author (up) Cai, Y.; Zhang, C.S.; Liu, S.; Wen, Z.; Zhang, A.L.; Guo, X.; Lu, C.; Xue, C.C. url  doi
openurl 
  Title Electroacupuncture for Poststroke Spasticity: A Systematic Review and Meta-Analysis Type of Study Journal Article
  Year 2017 Publication Archives of Physical Medicine and Rehabilitation Abbreviated Journal Arch Phys Med Rehabil  
  Volume 98 Issue 12 Pages 2578-2589.e4  
  Keywords Electroacupuncture/*methods; Humans; Muscle Spasticity/*rehabilitation; Stroke Rehabilitation/*methods; Upper Extremity; *Acupuncture; *Meta-Analysis; *Muscle spasticity; *Rehabilitation; *Stroke  
  Abstract OBJECTIVE: To evaluate the effects and safety of electroacupuncture (EA) for stroke patients with spasticity. DATA SOURCES: Five English databases (PubMed, EMBASE, CINAHL, Cochrane Central Register of Controlled Trials, Allied and Complementary Medicine Database) and 4 Chinese databases (Chinese Biomedical Database, Chinese National Knowledge Infrastructure, Chongqing VIP Database, Wanfang Database) were searched from their inception to September 2016. STUDY SELECTION: Randomized controlled trials were included if they measured spasticity with the Modified Ashworth Scale (MAS) in stroke patients and investigated the add-on effects of electroacupuncture to routine pharmacotherapy and rehabilitation therapies. DATA EXTRACTION: Information on patients, study design, treatment details and outcomes assessing spasticity severity, motor function, and activities of daily living was extracted. DATA SYNTHESIS: In total, 22 trials involving 1425 participants met the search criteria and were included. The estimated add-on effects of EA to reduce spasticity in the upper limbs as measured by the MAS (standardized mean difference [SMD]=-.57; 95% confidence interval [CI], -.84 to -.29), and to improve overall motor function as measured by the Fugl-Meyer Assessment of Sensorimotor Recovery (mean difference [MD]=10.60; 95% CI, 8.67-12.53) were significant. Significant add-on effects of EA were also shown for spasticity in the lower limbs, lower-limb motor function, and activities of daily living ([SMD=-.88; 95% CI, -1.42 to -.35;], [MD=4.42; 95% CI, .06-8.78], and [MD=6.85; 95% CI, 3.64-10.05], respectively), although with high heterogeneity. For upper-limb motor function, no significant add-on effects of EA were found. CONCLUSIONS: EA combined with conventional routine care has the potential of reducing spasticity in the upper and lower limbs and improving overall and lower extremity motor function and activities of daily living for patients with spasticity, within 180 days poststroke. Further studies of high methodological and reporting quality are needed to confirm the effects and safety of EA, and to explore the adequate and optimal protocol of EA for poststroke spasticity, incorporating a group of comprehensive outcome measures in different populations.  
  Address China-Australia International Research Centre for Chinese Medicine, School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia; Guangdong Provincial Hospital of Chinese Medicine (The Second Affiliated Hospital of Guangzhou University of Chinese Medicine), Guangdong Provincial Academy of Chinese Medical Sciences, and The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China. Electronic address: charlie.xue@rmit.edu.au  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes PMID:28455191 Approved no  
  Call Number OCOM @ refbase @ Serial 2871  
Permanent link to this record
 

 
Author (up) Cai, Y.; Zhang, C.S.; Liu, S.; Wen, Z.; Zhang, A.L.; Guo, X.; Lu, C.; Xue, C.C. url  doi
openurl 
  Title Electroacupuncture for Poststroke Spasticity: A Systematic Review and Meta-Analysis Type of Study Journal Article
  Year 2017 Publication Archives of Physical Medicine and Rehabilitation Abbreviated Journal Arch Phys Med Rehabil  
  Volume 98 Issue 12 Pages 2578-2589.e4  
  Keywords Electroacupuncture/*methods; Humans; Muscle Spasticity/*rehabilitation; Stroke Rehabilitation/*methods; Upper Extremity; *Acupuncture; *Meta-Analysis; *Muscle spasticity; *Rehabilitation; *Stroke  
  Abstract OBJECTIVE: To evaluate the effects and safety of electroacupuncture (EA) for stroke patients with spasticity. DATA SOURCES: Five English databases (PubMed, EMBASE, CINAHL, Cochrane Central Register of Controlled Trials, Allied and Complementary Medicine Database) and 4 Chinese databases (Chinese Biomedical Database, Chinese National Knowledge Infrastructure, Chongqing VIP Database, Wanfang Database) were searched from their inception to September 2016. STUDY SELECTION: Randomized controlled trials were included if they measured spasticity with the Modified Ashworth Scale (MAS) in stroke patients and investigated the add-on effects of electroacupuncture to routine pharmacotherapy and rehabilitation therapies. DATA EXTRACTION: Information on patients, study design, treatment details and outcomes assessing spasticity severity, motor function, and activities of daily living was extracted. DATA SYNTHESIS: In total, 22 trials involving 1425 participants met the search criteria and were included. The estimated add-on effects of EA to reduce spasticity in the upper limbs as measured by the MAS (standardized mean difference [SMD]=-.57; 95% confidence interval [CI], -.84 to -.29), and to improve overall motor function as measured by the Fugl-Meyer Assessment of Sensorimotor Recovery (mean difference [MD]=10.60; 95% CI, 8.67-12.53) were significant. Significant add-on effects of EA were also shown for spasticity in the lower limbs, lower-limb motor function, and activities of daily living ([SMD=-.88; 95% CI, -1.42 to -.35;], [MD=4.42; 95% CI, .06-8.78], and [MD=6.85; 95% CI, 3.64-10.05], respectively), although with high heterogeneity. For upper-limb motor function, no significant add-on effects of EA were found. CONCLUSIONS: EA combined with conventional routine care has the potential of reducing spasticity in the upper and lower limbs and improving overall and lower extremity motor function and activities of daily living for patients with spasticity, within 180 days poststroke. Further studies of high methodological and reporting quality are needed to confirm the effects and safety of EA, and to explore the adequate and optimal protocol of EA for poststroke spasticity, incorporating a group of comprehensive outcome measures in different populations.  
  Address China-Australia International Research Centre for Chinese Medicine, School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia; Guangdong Provincial Hospital of Chinese Medicine (The Second Affiliated Hospital of Guangzhou University of Chinese Medicine), Guangdong Provincial Academy of Chinese Medical Sciences, and The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China. Electronic address: charlie.xue@rmit.edu.au  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes PMID:28455191 Approved no  
  Call Number OCOM @ refbase @ Serial 2912  
Permanent link to this record
 

 
Author (up) Cai, Y.; Zhang, C.S.; Liu, S.; Wen, Z.; Zhang, A.L.; Guo, X.; Lu, C.; Xue, C.C. url  doi
openurl 
  Title Electroacupuncture for Poststroke Spasticity: A Systematic Review and Meta-Analysis Type of Study Journal Article
  Year 2017 Publication Archives of Physical Medicine and Rehabilitation Abbreviated Journal Arch Phys Med Rehabil  
  Volume 98 Issue 12 Pages 2578-2589.e4  
  Keywords Electroacupuncture/*methods; Humans; Muscle Spasticity/*rehabilitation; Stroke Rehabilitation/*methods; Upper Extremity; *Acupuncture; *Meta-Analysis; *Muscle spasticity; *Rehabilitation; *Stroke  
  Abstract OBJECTIVE: To evaluate the effects and safety of electroacupuncture (EA) for stroke patients with spasticity. DATA SOURCES: Five English databases (PubMed, EMBASE, CINAHL, Cochrane Central Register of Controlled Trials, Allied and Complementary Medicine Database) and 4 Chinese databases (Chinese Biomedical Database, Chinese National Knowledge Infrastructure, Chongqing VIP Database, Wanfang Database) were searched from their inception to September 2016. STUDY SELECTION: Randomized controlled trials were included if they measured spasticity with the Modified Ashworth Scale (MAS) in stroke patients and investigated the add-on effects of electroacupuncture to routine pharmacotherapy and rehabilitation therapies. DATA EXTRACTION: Information on patients, study design, treatment details and outcomes assessing spasticity severity, motor function, and activities of daily living was extracted. DATA SYNTHESIS: In total, 22 trials involving 1425 participants met the search criteria and were included. The estimated add-on effects of EA to reduce spasticity in the upper limbs as measured by the MAS (standardized mean difference [SMD]=-.57; 95% confidence interval [CI], -.84 to -.29), and to improve overall motor function as measured by the Fugl-Meyer Assessment of Sensorimotor Recovery (mean difference [MD]=10.60; 95% CI, 8.67-12.53) were significant. Significant add-on effects of EA were also shown for spasticity in the lower limbs, lower-limb motor function, and activities of daily living ([SMD=-.88; 95% CI, -1.42 to -.35;], [MD=4.42; 95% CI, .06-8.78], and [MD=6.85; 95% CI, 3.64-10.05], respectively), although with high heterogeneity. For upper-limb motor function, no significant add-on effects of EA were found. CONCLUSIONS: EA combined with conventional routine care has the potential of reducing spasticity in the upper and lower limbs and improving overall and lower extremity motor function and activities of daily living for patients with spasticity, within 180 days poststroke. Further studies of high methodological and reporting quality are needed to confirm the effects and safety of EA, and to explore the adequate and optimal protocol of EA for poststroke spasticity, incorporating a group of comprehensive outcome measures in different populations.  
  Address China-Australia International Research Centre for Chinese Medicine, School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia; Guangdong Provincial Hospital of Chinese Medicine (The Second Affiliated Hospital of Guangzhou University of Chinese Medicine), Guangdong Provincial Academy of Chinese Medical Sciences, and The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China. Electronic address: charlie.xue@rmit.edu.au  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes PMID:28455191 Approved no  
  Call Number OCOM @ refbase @ Serial 2953  
Permanent link to this record
 

 
Author (up) Chang, S.-C.; Hsu, C.-H.; Hsu, C.-K.; Yang, S.S.-D.; Chang, S.-J. url  doi
openurl 
  Title The efficacy of acupuncture in managing patients with chronic prostatitis/chronic pelvic pain syndrome: A systemic review and meta-analysis Type of Study Journal Article
  Year 2017 Publication Neurourology and Urodynamics Abbreviated Journal Neurourol Urodyn  
  Volume 36 Issue 2 Pages 474-481  
  Keywords acupuncture; chronic pelvic pain syndrome; chronic prostatitis; meta-analysis; prostate pain syndrome; review  
  Abstract OBJECTIVES: This study aimed to systemically review published randomized control trials that compared the efficacy of acupuncture with sham acupuncture or standard medical treatment as management for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). METHODS: A systemic search of the PubMED(R), Embase, Airiti Library, and China Journal Net was done for all randomized controlled trials that compared the efficacy of acupuncture with sham acupuncture, alpha-blockers, antibiotics, or anti-inflammatory drugs in patients with CP/CPPS. Two investigators conducted the literature search, quality assessment, and data extraction. The data were then analyzed using the Cochrane Collaboration Review Manager (RevMan(R), version 5.3). The study endpoints were response rate, the National Institute of Health-Chronic Prostatitis Index (NIH-CPSI), and the International Prostate symptom score (IPSS) reduction. RESULTS: Three and four randomized controlled trials compared acupuncture with sham acupuncture (n = 101 vs. 103) and medical treatment (n = 156 vs. 138), respectively. The results revealed that acupuncture was superior to sham acupuncture as regards response rate (OR: 5.15, 95%CI: 2.72-9.75; P < 0.01), NIH-CPSI (WMD: -6.09, 95%CI: -7.85 to -4.33), and IPSS (WMD: -2.44, 95%CI: -4.86 to -0.03; P = 0.05) reductions, therefore, excluding the placebo effect. Compared to standard medical treatments, acupuncture had a significantly higher response rate (OR: 3.57, 95%CI: 1.78-7.15; P < 0.01). CONCLUSIONS: Acupuncture has promising efficacy for patients with CP/CPPS. Compared to standard medical treatment, it has better efficacy. Thus, it may also serve as a standard treatment option when available. Neurourol. Urodynam. 36:474-481, 2017. (c) 2016 Wiley Periodicals, Inc.  
  Address Division of Urology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, School of Medicine, Buddhist Tzu Chi University, New Taipei City, Hualien, Taiwan  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes PMID:26741647 Approved no  
  Call Number OCOM @ refbase @ Serial 2219  
Permanent link to this record
 

 
Author (up) Chaudhry, F.A. url  doi
openurl 
  Title Effectiveness of dry needling and high-volume image-guided injection in the management of chronic mid-portion Achilles tendinopathy in adult population: a literature review Type of Study Systematic Review
  Year 2017 Publication European Journal of Orthopaedic Surgery & Traumatology : Orthopedie Traumatologie Abbreviated Journal Eur J Orthop Surg Traumatol  
  Volume 27 Issue 4 Pages 441-448  
  Keywords AcuTrials; Systematic Review; Pain; Musculoskeletal Diseases; Achilles Tendinopathy; Dry Needling; High-volume image-guided injection  
  Abstract Achilles tendinopathy is a common overuse condition affecting the adult population. The incidence is on the rise because of greater participation of people in recreational or competitive sporting activities. There are several treatment options available both non-operative and operative. Ultrasound-guided dry needling and high-volume image-guided injection is relatively a new procedure. The aim of this study was to find out the effectiveness of dry needling and HVIGI in the management of mid-portion chronic Achilles tendinopathy by performing a literature review. Search strategy was devised to find the suitable articles for critical appraisal using the electronic databases. Four articles were selected for critical appraisal, and these papers showed good short- to long-term results of image-guided high-volume injection in the management of Achilles tendinopathy. We conclude that high-volume image-guided injection is effective in the management of Achilles tendinopathy. It provides good short- and medium-term relief of symptoms. It should be considered as one of the many options available for this condition.  
  Address The University of Warwick, Coventry, CV4 7AL, UK. fouad.chaudhry@doctors.org.uk  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition Pain
  Disease Category Pain OCSI Score  
  Notes PMID:28424882 Approved yes  
  Call Number OCOM @ refbase @ Serial 2201  
Permanent link to this record
 

 
Author (up) Chavez, L.M.; Huang, S.-S.; MacDonald, I.; Lin, J.-G.; Lee, Y.-C.; Chen, Y.-H. url  doi
openurl 
  Title Mechanisms of Acupuncture Therapy in Ischemic Stroke Rehabilitation: A Literature Review of Basic Studies Type of Study Journal Article
  Year 2017 Publication International Journal of Molecular Sciences Abbreviated Journal Int J Mol Sci  
  Volume 18 Issue 11 Pages  
  Keywords acupuncture; basic research; cerebral ischemia; rehabilitation; stroke  
  Abstract Acupuncture is recommended by the World Health Organization (WHO) as an alternative and complementary strategy for stroke treatment and for improving stroke care. Clinical trial and meta-analysis findings have demonstrated the efficacy of acupuncture in improving balance function, reducing spasticity, and increasing muscle strength and general well-being post-stroke. The mechanisms underlying the beneficial effects of acupuncture in stroke rehabilitation remain unclear. The aim of this study was to conduct a literature review, summarize the current known mechanisms in ischemic stroke rehabilitation through acupuncture and electroacupuncture (EA) therapy, and to detail the frequently used acupoints implicated in these effects. The evidence in this review indicates that five major different mechanisms are involved in the beneficial effects of acupuncture/EA on ischemic stroke rehabilitation: (1) Promotion of neurogenesis and cell proliferation in the central nervous system (CNS); (2) Regulation of cerebral blood flow in the ischemic area; (3) Anti-apoptosis in the ischemic area; (4) Regulation of neurochemicals; and, (5) Improvement of impaired long-term potentiation (LTP) and memory after stroke. The most frequently used acupoints in basic studies include Baihui (GV20), Zusanli (ST36), Quchi (LI11), Shuigou (GV26), Dazhui (GV14), and Hegu (LI4). Our findings show that acupuncture exerts a beneficial effect on ischemic stroke through modulation of different mechanisms originating in the CNS.  
  Address Department of Photonics and Communication Engineering, Asia University, Taichung 41354, Taiwan. yihungchen@mail.cmu.edu.tw  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes PMID:29143805; PMCID:PMC5713240 Approved no  
  Call Number OCOM @ refbase @ Serial 2449  
Permanent link to this record
 

 
Author (up) Chavez, L.M.; Huang, S.-S.; MacDonald, I.; Lin, J.-G.; Lee, Y.-C.; Chen, Y.-H. url  doi
openurl 
  Title Mechanisms of Acupuncture Therapy in Ischemic Stroke Rehabilitation: A Literature Review of Basic Studies Type of Study Journal Article
  Year 2017 Publication International Journal of Molecular Sciences Abbreviated Journal Int J Mol Sci  
  Volume 18 Issue 11 Pages  
  Keywords acupuncture; basic research; cerebral ischemia; rehabilitation; stroke  
  Abstract Acupuncture is recommended by the World Health Organization (WHO) as an alternative and complementary strategy for stroke treatment and for improving stroke care. Clinical trial and meta-analysis findings have demonstrated the efficacy of acupuncture in improving balance function, reducing spasticity, and increasing muscle strength and general well-being post-stroke. The mechanisms underlying the beneficial effects of acupuncture in stroke rehabilitation remain unclear. The aim of this study was to conduct a literature review, summarize the current known mechanisms in ischemic stroke rehabilitation through acupuncture and electroacupuncture (EA) therapy, and to detail the frequently used acupoints implicated in these effects. The evidence in this review indicates that five major different mechanisms are involved in the beneficial effects of acupuncture/EA on ischemic stroke rehabilitation: (1) Promotion of neurogenesis and cell proliferation in the central nervous system (CNS); (2) Regulation of cerebral blood flow in the ischemic area; (3) Anti-apoptosis in the ischemic area; (4) Regulation of neurochemicals; and, (5) Improvement of impaired long-term potentiation (LTP) and memory after stroke. The most frequently used acupoints in basic studies include Baihui (GV20), Zusanli (ST36), Quchi (LI11), Shuigou (GV26), Dazhui (GV14), and Hegu (LI4). Our findings show that acupuncture exerts a beneficial effect on ischemic stroke through modulation of different mechanisms originating in the CNS.  
  Address Department of Photonics and Communication Engineering, Asia University, Taichung 41354, Taiwan. yihungchen@mail.cmu.edu.tw  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes PMID:29143805; PMCID:PMC5713240 Approved no  
  Call Number OCOM @ refbase @ Serial 2490  
Permanent link to this record
 

 
Author (up) Chavez, L.M.; Huang, S.-S.; MacDonald, I.; Lin, J.-G.; Lee, Y.-C.; Chen, Y.-H. url  doi
openurl 
  Title Mechanisms of Acupuncture Therapy in Ischemic Stroke Rehabilitation: A Literature Review of Basic Studies Type of Study Journal Article
  Year 2017 Publication International Journal of Molecular Sciences Abbreviated Journal Int J Mol Sci  
  Volume 18 Issue 11 Pages  
  Keywords acupuncture; basic research; cerebral ischemia; rehabilitation; stroke  
  Abstract Acupuncture is recommended by the World Health Organization (WHO) as an alternative and complementary strategy for stroke treatment and for improving stroke care. Clinical trial and meta-analysis findings have demonstrated the efficacy of acupuncture in improving balance function, reducing spasticity, and increasing muscle strength and general well-being post-stroke. The mechanisms underlying the beneficial effects of acupuncture in stroke rehabilitation remain unclear. The aim of this study was to conduct a literature review, summarize the current known mechanisms in ischemic stroke rehabilitation through acupuncture and electroacupuncture (EA) therapy, and to detail the frequently used acupoints implicated in these effects. The evidence in this review indicates that five major different mechanisms are involved in the beneficial effects of acupuncture/EA on ischemic stroke rehabilitation: (1) Promotion of neurogenesis and cell proliferation in the central nervous system (CNS); (2) Regulation of cerebral blood flow in the ischemic area; (3) Anti-apoptosis in the ischemic area; (4) Regulation of neurochemicals; and, (5) Improvement of impaired long-term potentiation (LTP) and memory after stroke. The most frequently used acupoints in basic studies include Baihui (GV20), Zusanli (ST36), Quchi (LI11), Shuigou (GV26), Dazhui (GV14), and Hegu (LI4). Our findings show that acupuncture exerts a beneficial effect on ischemic stroke through modulation of different mechanisms originating in the CNS.  
  Address Department of Photonics and Communication Engineering, Asia University, Taichung 41354, Taiwan. yihungchen@mail.cmu.edu.tw  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes PMID:29143805; PMCID:PMC5713240 Approved no  
  Call Number OCOM @ refbase @ Serial 2531  
Permanent link to this record
 

 
Author (up) Chavez, L.M.; Huang, S.-S.; MacDonald, I.; Lin, J.-G.; Lee, Y.-C.; Chen, Y.-H. url  doi
openurl 
  Title Mechanisms of Acupuncture Therapy in Ischemic Stroke Rehabilitation: A Literature Review of Basic Studies Type of Study Journal Article
  Year 2017 Publication International Journal of Molecular Sciences Abbreviated Journal Int J Mol Sci  
  Volume 18 Issue 11 Pages  
  Keywords acupuncture; basic research; cerebral ischemia; rehabilitation; stroke  
  Abstract Acupuncture is recommended by the World Health Organization (WHO) as an alternative and complementary strategy for stroke treatment and for improving stroke care. Clinical trial and meta-analysis findings have demonstrated the efficacy of acupuncture in improving balance function, reducing spasticity, and increasing muscle strength and general well-being post-stroke. The mechanisms underlying the beneficial effects of acupuncture in stroke rehabilitation remain unclear. The aim of this study was to conduct a literature review, summarize the current known mechanisms in ischemic stroke rehabilitation through acupuncture and electroacupuncture (EA) therapy, and to detail the frequently used acupoints implicated in these effects. The evidence in this review indicates that five major different mechanisms are involved in the beneficial effects of acupuncture/EA on ischemic stroke rehabilitation: (1) Promotion of neurogenesis and cell proliferation in the central nervous system (CNS); (2) Regulation of cerebral blood flow in the ischemic area; (3) Anti-apoptosis in the ischemic area; (4) Regulation of neurochemicals; and, (5) Improvement of impaired long-term potentiation (LTP) and memory after stroke. The most frequently used acupoints in basic studies include Baihui (GV20), Zusanli (ST36), Quchi (LI11), Shuigou (GV26), Dazhui (GV14), and Hegu (LI4). Our findings show that acupuncture exerts a beneficial effect on ischemic stroke through modulation of different mechanisms originating in the CNS.  
  Address Department of Photonics and Communication Engineering, Asia University, Taichung 41354, Taiwan. yihungchen@mail.cmu.edu.tw  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes PMID:29143805; PMCID:PMC5713240 Approved no  
  Call Number OCOM @ refbase @ Serial 2572  
Permanent link to this record
 

 
Author (up) Chavez, L.M.; Huang, S.-S.; MacDonald, I.; Lin, J.-G.; Lee, Y.-C.; Chen, Y.-H. url  doi
openurl 
  Title Mechanisms of Acupuncture Therapy in Ischemic Stroke Rehabilitation: A Literature Review of Basic Studies Type of Study Journal Article
  Year 2017 Publication International Journal of Molecular Sciences Abbreviated Journal Int J Mol Sci  
  Volume 18 Issue 11 Pages  
  Keywords acupuncture; basic research; cerebral ischemia; rehabilitation; stroke  
  Abstract Acupuncture is recommended by the World Health Organization (WHO) as an alternative and complementary strategy for stroke treatment and for improving stroke care. Clinical trial and meta-analysis findings have demonstrated the efficacy of acupuncture in improving balance function, reducing spasticity, and increasing muscle strength and general well-being post-stroke. The mechanisms underlying the beneficial effects of acupuncture in stroke rehabilitation remain unclear. The aim of this study was to conduct a literature review, summarize the current known mechanisms in ischemic stroke rehabilitation through acupuncture and electroacupuncture (EA) therapy, and to detail the frequently used acupoints implicated in these effects. The evidence in this review indicates that five major different mechanisms are involved in the beneficial effects of acupuncture/EA on ischemic stroke rehabilitation: (1) Promotion of neurogenesis and cell proliferation in the central nervous system (CNS); (2) Regulation of cerebral blood flow in the ischemic area; (3) Anti-apoptosis in the ischemic area; (4) Regulation of neurochemicals; and, (5) Improvement of impaired long-term potentiation (LTP) and memory after stroke. The most frequently used acupoints in basic studies include Baihui (GV20), Zusanli (ST36), Quchi (LI11), Shuigou (GV26), Dazhui (GV14), and Hegu (LI4). Our findings show that acupuncture exerts a beneficial effect on ischemic stroke through modulation of different mechanisms originating in the CNS.  
  Address Department of Photonics and Communication Engineering, Asia University, Taichung 41354, Taiwan. yihungchen@mail.cmu.edu.tw  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes PMID:29143805; PMCID:PMC5713240 Approved no  
  Call Number OCOM @ refbase @ Serial 2613  
Permanent link to this record
 

 
Author (up) Chavez, L.M.; Huang, S.-S.; MacDonald, I.; Lin, J.-G.; Lee, Y.-C.; Chen, Y.-H. url  doi
openurl 
  Title Mechanisms of Acupuncture Therapy in Ischemic Stroke Rehabilitation: A Literature Review of Basic Studies Type of Study Journal Article
  Year 2017 Publication International Journal of Molecular Sciences Abbreviated Journal Int J Mol Sci  
  Volume 18 Issue 11 Pages  
  Keywords acupuncture; basic research; cerebral ischemia; rehabilitation; stroke  
  Abstract Acupuncture is recommended by the World Health Organization (WHO) as an alternative and complementary strategy for stroke treatment and for improving stroke care. Clinical trial and meta-analysis findings have demonstrated the efficacy of acupuncture in improving balance function, reducing spasticity, and increasing muscle strength and general well-being post-stroke. The mechanisms underlying the beneficial effects of acupuncture in stroke rehabilitation remain unclear. The aim of this study was to conduct a literature review, summarize the current known mechanisms in ischemic stroke rehabilitation through acupuncture and electroacupuncture (EA) therapy, and to detail the frequently used acupoints implicated in these effects. The evidence in this review indicates that five major different mechanisms are involved in the beneficial effects of acupuncture/EA on ischemic stroke rehabilitation: (1) Promotion of neurogenesis and cell proliferation in the central nervous system (CNS); (2) Regulation of cerebral blood flow in the ischemic area; (3) Anti-apoptosis in the ischemic area; (4) Regulation of neurochemicals; and, (5) Improvement of impaired long-term potentiation (LTP) and memory after stroke. The most frequently used acupoints in basic studies include Baihui (GV20), Zusanli (ST36), Quchi (LI11), Shuigou (GV26), Dazhui (GV14), and Hegu (LI4). Our findings show that acupuncture exerts a beneficial effect on ischemic stroke through modulation of different mechanisms originating in the CNS.  
  Address Department of Photonics and Communication Engineering, Asia University, Taichung 41354, Taiwan. yihungchen@mail.cmu.edu.tw  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes PMID:29143805; PMCID:PMC5713240 Approved no  
  Call Number OCOM @ refbase @ Serial 2665  
Permanent link to this record
 

 
Author (up) Chavez, L.M.; Huang, S.-S.; MacDonald, I.; Lin, J.-G.; Lee, Y.-C.; Chen, Y.-H. url  doi
openurl 
  Title Mechanisms of Acupuncture Therapy in Ischemic Stroke Rehabilitation: A Literature Review of Basic Studies Type of Study Journal Article
  Year 2017 Publication International Journal of Molecular Sciences Abbreviated Journal Int J Mol Sci  
  Volume 18 Issue 11 Pages  
  Keywords acupuncture; basic research; cerebral ischemia; rehabilitation; stroke  
  Abstract Acupuncture is recommended by the World Health Organization (WHO) as an alternative and complementary strategy for stroke treatment and for improving stroke care. Clinical trial and meta-analysis findings have demonstrated the efficacy of acupuncture in improving balance function, reducing spasticity, and increasing muscle strength and general well-being post-stroke. The mechanisms underlying the beneficial effects of acupuncture in stroke rehabilitation remain unclear. The aim of this study was to conduct a literature review, summarize the current known mechanisms in ischemic stroke rehabilitation through acupuncture and electroacupuncture (EA) therapy, and to detail the frequently used acupoints implicated in these effects. The evidence in this review indicates that five major different mechanisms are involved in the beneficial effects of acupuncture/EA on ischemic stroke rehabilitation: (1) Promotion of neurogenesis and cell proliferation in the central nervous system (CNS); (2) Regulation of cerebral blood flow in the ischemic area; (3) Anti-apoptosis in the ischemic area; (4) Regulation of neurochemicals; and, (5) Improvement of impaired long-term potentiation (LTP) and memory after stroke. The most frequently used acupoints in basic studies include Baihui (GV20), Zusanli (ST36), Quchi (LI11), Shuigou (GV26), Dazhui (GV14), and Hegu (LI4). Our findings show that acupuncture exerts a beneficial effect on ischemic stroke through modulation of different mechanisms originating in the CNS.  
  Address Department of Photonics and Communication Engineering, Asia University, Taichung 41354, Taiwan. yihungchen@mail.cmu.edu.tw  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes PMID:29143805; PMCID:PMC5713240 Approved no  
  Call Number OCOM @ refbase @ Serial 2706  
Permanent link to this record
 

 
Author (up) Chavez, L.M.; Huang, S.-S.; MacDonald, I.; Lin, J.-G.; Lee, Y.-C.; Chen, Y.-H. url  doi
openurl 
  Title Mechanisms of Acupuncture Therapy in Ischemic Stroke Rehabilitation: A Literature Review of Basic Studies Type of Study Journal Article
  Year 2017 Publication International Journal of Molecular Sciences Abbreviated Journal Int J Mol Sci  
  Volume 18 Issue 11 Pages  
  Keywords acupuncture; basic research; cerebral ischemia; rehabilitation; stroke  
  Abstract Acupuncture is recommended by the World Health Organization (WHO) as an alternative and complementary strategy for stroke treatment and for improving stroke care. Clinical trial and meta-analysis findings have demonstrated the efficacy of acupuncture in improving balance function, reducing spasticity, and increasing muscle strength and general well-being post-stroke. The mechanisms underlying the beneficial effects of acupuncture in stroke rehabilitation remain unclear. The aim of this study was to conduct a literature review, summarize the current known mechanisms in ischemic stroke rehabilitation through acupuncture and electroacupuncture (EA) therapy, and to detail the frequently used acupoints implicated in these effects. The evidence in this review indicates that five major different mechanisms are involved in the beneficial effects of acupuncture/EA on ischemic stroke rehabilitation: (1) Promotion of neurogenesis and cell proliferation in the central nervous system (CNS); (2) Regulation of cerebral blood flow in the ischemic area; (3) Anti-apoptosis in the ischemic area; (4) Regulation of neurochemicals; and, (5) Improvement of impaired long-term potentiation (LTP) and memory after stroke. The most frequently used acupoints in basic studies include Baihui (GV20), Zusanli (ST36), Quchi (LI11), Shuigou (GV26), Dazhui (GV14), and Hegu (LI4). Our findings show that acupuncture exerts a beneficial effect on ischemic stroke through modulation of different mechanisms originating in the CNS.  
  Address Department of Photonics and Communication Engineering, Asia University, Taichung 41354, Taiwan. yihungchen@mail.cmu.edu.tw  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes PMID:29143805; PMCID:PMC5713240 Approved no  
  Call Number OCOM @ refbase @ Serial 2736  
Permanent link to this record
 

 
Author (up) Chavez, L.M.; Huang, S.-S.; MacDonald, I.; Lin, J.-G.; Lee, Y.-C.; Chen, Y.-H. url  doi
openurl 
  Title Mechanisms of Acupuncture Therapy in Ischemic Stroke Rehabilitation: A Literature Review of Basic Studies Type of Study Journal Article
  Year 2017 Publication International Journal of Molecular Sciences Abbreviated Journal Int J Mol Sci  
  Volume 18 Issue 11 Pages  
  Keywords acupuncture; basic research; cerebral ischemia; rehabilitation; stroke  
  Abstract Acupuncture is recommended by the World Health Organization (WHO) as an alternative and complementary strategy for stroke treatment and for improving stroke care. Clinical trial and meta-analysis findings have demonstrated the efficacy of acupuncture in improving balance function, reducing spasticity, and increasing muscle strength and general well-being post-stroke. The mechanisms underlying the beneficial effects of acupuncture in stroke rehabilitation remain unclear. The aim of this study was to conduct a literature review, summarize the current known mechanisms in ischemic stroke rehabilitation through acupuncture and electroacupuncture (EA) therapy, and to detail the frequently used acupoints implicated in these effects. The evidence in this review indicates that five major different mechanisms are involved in the beneficial effects of acupuncture/EA on ischemic stroke rehabilitation: (1) Promotion of neurogenesis and cell proliferation in the central nervous system (CNS); (2) Regulation of cerebral blood flow in the ischemic area; (3) Anti-apoptosis in the ischemic area; (4) Regulation of neurochemicals; and, (5) Improvement of impaired long-term potentiation (LTP) and memory after stroke. The most frequently used acupoints in basic studies include Baihui (GV20), Zusanli (ST36), Quchi (LI11), Shuigou (GV26), Dazhui (GV14), and Hegu (LI4). Our findings show that acupuncture exerts a beneficial effect on ischemic stroke through modulation of different mechanisms originating in the CNS.  
  Address Department of Photonics and Communication Engineering, Asia University, Taichung 41354, Taiwan. yihungchen@mail.cmu.edu.tw  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes PMID:29143805; PMCID:PMC5713240 Approved no  
  Call Number OCOM @ refbase @ Serial 2777  
Permanent link to this record
 

 
Author (up) Chavez, L.M.; Huang, S.-S.; MacDonald, I.; Lin, J.-G.; Lee, Y.-C.; Chen, Y.-H. url  doi
openurl 
  Title Mechanisms of Acupuncture Therapy in Ischemic Stroke Rehabilitation: A Literature Review of Basic Studies Type of Study Journal Article
  Year 2017 Publication International Journal of Molecular Sciences Abbreviated Journal Int J Mol Sci  
  Volume 18 Issue 11 Pages  
  Keywords acupuncture; basic research; cerebral ischemia; rehabilitation; stroke  
  Abstract Acupuncture is recommended by the World Health Organization (WHO) as an alternative and complementary strategy for stroke treatment and for improving stroke care. Clinical trial and meta-analysis findings have demonstrated the efficacy of acupuncture in improving balance function, reducing spasticity, and increasing muscle strength and general well-being post-stroke. The mechanisms underlying the beneficial effects of acupuncture in stroke rehabilitation remain unclear. The aim of this study was to conduct a literature review, summarize the current known mechanisms in ischemic stroke rehabilitation through acupuncture and electroacupuncture (EA) therapy, and to detail the frequently used acupoints implicated in these effects. The evidence in this review indicates that five major different mechanisms are involved in the beneficial effects of acupuncture/EA on ischemic stroke rehabilitation: (1) Promotion of neurogenesis and cell proliferation in the central nervous system (CNS); (2) Regulation of cerebral blood flow in the ischemic area; (3) Anti-apoptosis in the ischemic area; (4) Regulation of neurochemicals; and, (5) Improvement of impaired long-term potentiation (LTP) and memory after stroke. The most frequently used acupoints in basic studies include Baihui (GV20), Zusanli (ST36), Quchi (LI11), Shuigou (GV26), Dazhui (GV14), and Hegu (LI4). Our findings show that acupuncture exerts a beneficial effect on ischemic stroke through modulation of different mechanisms originating in the CNS.  
  Address Department of Photonics and Communication Engineering, Asia University, Taichung 41354, Taiwan. yihungchen@mail.cmu.edu.tw  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes PMID:29143805; PMCID:PMC5713240 Approved no  
  Call Number OCOM @ refbase @ Serial 2818  
Permanent link to this record
 

 
Author (up) Chavez, L.M.; Huang, S.-S.; MacDonald, I.; Lin, J.-G.; Lee, Y.-C.; Chen, Y.-H. url  doi
openurl 
  Title Mechanisms of Acupuncture Therapy in Ischemic Stroke Rehabilitation: A Literature Review of Basic Studies Type of Study Journal Article
  Year 2017 Publication International Journal of Molecular Sciences Abbreviated Journal Int J Mol Sci  
  Volume 18 Issue 11 Pages  
  Keywords acupuncture; basic research; cerebral ischemia; rehabilitation; stroke  
  Abstract Acupuncture is recommended by the World Health Organization (WHO) as an alternative and complementary strategy for stroke treatment and for improving stroke care. Clinical trial and meta-analysis findings have demonstrated the efficacy of acupuncture in improving balance function, reducing spasticity, and increasing muscle strength and general well-being post-stroke. The mechanisms underlying the beneficial effects of acupuncture in stroke rehabilitation remain unclear. The aim of this study was to conduct a literature review, summarize the current known mechanisms in ischemic stroke rehabilitation through acupuncture and electroacupuncture (EA) therapy, and to detail the frequently used acupoints implicated in these effects. The evidence in this review indicates that five major different mechanisms are involved in the beneficial effects of acupuncture/EA on ischemic stroke rehabilitation: (1) Promotion of neurogenesis and cell proliferation in the central nervous system (CNS); (2) Regulation of cerebral blood flow in the ischemic area; (3) Anti-apoptosis in the ischemic area; (4) Regulation of neurochemicals; and, (5) Improvement of impaired long-term potentiation (LTP) and memory after stroke. The most frequently used acupoints in basic studies include Baihui (GV20), Zusanli (ST36), Quchi (LI11), Shuigou (GV26), Dazhui (GV14), and Hegu (LI4). Our findings show that acupuncture exerts a beneficial effect on ischemic stroke through modulation of different mechanisms originating in the CNS.  
  Address Department of Photonics and Communication Engineering, Asia University, Taichung 41354, Taiwan. yihungchen@mail.cmu.edu.tw  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes PMID:29143805; PMCID:PMC5713240 Approved no  
  Call Number OCOM @ refbase @ Serial 2859  
Permanent link to this record
 

 
Author (up) Chavez, L.M.; Huang, S.-S.; MacDonald, I.; Lin, J.-G.; Lee, Y.-C.; Chen, Y.-H. url  doi
openurl 
  Title Mechanisms of Acupuncture Therapy in Ischemic Stroke Rehabilitation: A Literature Review of Basic Studies Type of Study Journal Article
  Year 2017 Publication International Journal of Molecular Sciences Abbreviated Journal Int J Mol Sci  
  Volume 18 Issue 11 Pages  
  Keywords acupuncture; basic research; cerebral ischemia; rehabilitation; stroke  
  Abstract Acupuncture is recommended by the World Health Organization (WHO) as an alternative and complementary strategy for stroke treatment and for improving stroke care. Clinical trial and meta-analysis findings have demonstrated the efficacy of acupuncture in improving balance function, reducing spasticity, and increasing muscle strength and general well-being post-stroke. The mechanisms underlying the beneficial effects of acupuncture in stroke rehabilitation remain unclear. The aim of this study was to conduct a literature review, summarize the current known mechanisms in ischemic stroke rehabilitation through acupuncture and electroacupuncture (EA) therapy, and to detail the frequently used acupoints implicated in these effects. The evidence in this review indicates that five major different mechanisms are involved in the beneficial effects of acupuncture/EA on ischemic stroke rehabilitation: (1) Promotion of neurogenesis and cell proliferation in the central nervous system (CNS); (2) Regulation of cerebral blood flow in the ischemic area; (3) Anti-apoptosis in the ischemic area; (4) Regulation of neurochemicals; and, (5) Improvement of impaired long-term potentiation (LTP) and memory after stroke. The most frequently used acupoints in basic studies include Baihui (GV20), Zusanli (ST36), Quchi (LI11), Shuigou (GV26), Dazhui (GV14), and Hegu (LI4). Our findings show that acupuncture exerts a beneficial effect on ischemic stroke through modulation of different mechanisms originating in the CNS.  
  Address Department of Photonics and Communication Engineering, Asia University, Taichung 41354, Taiwan. yihungchen@mail.cmu.edu.tw  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes PMID:29143805; PMCID:PMC5713240 Approved no  
  Call Number OCOM @ refbase @ Serial 2900  
Permanent link to this record
 

 
Author (up) Chavez, L.M.; Huang, S.-S.; MacDonald, I.; Lin, J.-G.; Lee, Y.-C.; Chen, Y.-H. url  doi
openurl 
  Title Mechanisms of Acupuncture Therapy in Ischemic Stroke Rehabilitation: A Literature Review of Basic Studies Type of Study Journal Article
  Year 2017 Publication International Journal of Molecular Sciences Abbreviated Journal Int J Mol Sci  
  Volume 18 Issue 11 Pages  
  Keywords acupuncture; basic research; cerebral ischemia; rehabilitation; stroke  
  Abstract Acupuncture is recommended by the World Health Organization (WHO) as an alternative and complementary strategy for stroke treatment and for improving stroke care. Clinical trial and meta-analysis findings have demonstrated the efficacy of acupuncture in improving balance function, reducing spasticity, and increasing muscle strength and general well-being post-stroke. The mechanisms underlying the beneficial effects of acupuncture in stroke rehabilitation remain unclear. The aim of this study was to conduct a literature review, summarize the current known mechanisms in ischemic stroke rehabilitation through acupuncture and electroacupuncture (EA) therapy, and to detail the frequently used acupoints implicated in these effects. The evidence in this review indicates that five major different mechanisms are involved in the beneficial effects of acupuncture/EA on ischemic stroke rehabilitation: (1) Promotion of neurogenesis and cell proliferation in the central nervous system (CNS); (2) Regulation of cerebral blood flow in the ischemic area; (3) Anti-apoptosis in the ischemic area; (4) Regulation of neurochemicals; and, (5) Improvement of impaired long-term potentiation (LTP) and memory after stroke. The most frequently used acupoints in basic studies include Baihui (GV20), Zusanli (ST36), Quchi (LI11), Shuigou (GV26), Dazhui (GV14), and Hegu (LI4). Our findings show that acupuncture exerts a beneficial effect on ischemic stroke through modulation of different mechanisms originating in the CNS.  
  Address Department of Photonics and Communication Engineering, Asia University, Taichung 41354, Taiwan. yihungchen@mail.cmu.edu.tw  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes PMID:29143805; PMCID:PMC5713240 Approved no  
  Call Number OCOM @ refbase @ Serial 2941  
Permanent link to this record
 

 
Author (up) Cheng, C.-S.; Chen, L.-Y.; Ning, Z.-Y.; Zhang, C.-Y.; Chen, H.; Chen, Z.; Zhu, X.-Y.; Xie, J. url  doi
openurl 
  Title Acupuncture for cancer-related fatigue in lung cancer patients: a randomized, double blind, placebo-controlled pilot trial Type of Study Journal Article
  Year 2017 Publication Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer Abbreviated Journal Support Care Cancer  
  Volume 25 Issue 12 Pages 3807-3814  
  Keywords Acupuncture Points; Acupuncture Therapy/*methods; Double-Blind Method; Fatigue/etiology/*therapy; Feasibility Studies; Female; Humans; Lung Neoplasms/pathology/*physiopathology/*therapy; Male; Middle Aged; Neoplasm Staging; Physical Therapy Modalities; Pilot Projects; Quality of Life; *Acupuncture; *Cancer-related fatigue; *Lung cancer; *Quality of life  
  Abstract BACKGROUND: Cancer-related fatigue (CRF) is a distressing symptom that is the most common unpleasant side effect experienced by lung cancer patients and is challenging for clinical care workers to manage. METHODS: We performed a randomized, double-blind, placebo-controlled pilot trial to evaluate the clinical effect of acupuncture on CRF in lung cancer patients. Twenty-eight patients presenting with CRF were randomly assigned to active acupuncture or placebo acupuncture groups to receive acupoint stimulation (LI-4, Ren-6, St-36, KI-3, and Sp-6) twice per week for 4 weeks, followed by 2 weeks of follow-up. The primary outcome was the change in intensity of CFR based on the Chinese version of the Brief Fatigue Inventory (BFI-C). As the secondary endpoint, the Functional Assessment of Cancer Therapy-Lung Cancer Subscale (FACT-LCS) was adopted to assess the influence of acupuncture on patients' quality of life (QOL). Adverse events and safety of treatments were monitored throughout the trial. RESULTS: Our pilot study demonstrated feasibility among patients with appropriate inclusion criteria and good compliance with acupuncture treatment. A significant reduction in the BFI-C score was observed at 2 weeks in the 14 participants who received active acupuncture compared with those receiving the placebo (P < 0.01). At week 6, symptoms further improved according to the BFI-C (P < 0.001) and the FACT-LCS (P = 0.002). There were no significant differences in the incidence of adverse events in either group (P > 0.05). CONCLUSION: Fatigue is a common symptom experienced by lung cancer patients. Acupuncture may be a safe and feasible optional method for adjunctive treatment in cancer palliative care, and appropriately powered trials are warranted to evaluate the effects of acupuncture.  
  Address Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong'An Road, Shanghai, 200032, China. isable624@163.com  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes PMID:28707168 Approved no  
  Call Number OCOM @ refbase @ Serial 2457  
Permanent link to this record
 

 
Author (up) Cheng, C.-S.; Chen, L.-Y.; Ning, Z.-Y.; Zhang, C.-Y.; Chen, H.; Chen, Z.; Zhu, X.-Y.; Xie, J. url  doi
openurl 
  Title Acupuncture for cancer-related fatigue in lung cancer patients: a randomized, double blind, placebo-controlled pilot trial Type of Study Journal Article
  Year 2017 Publication Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer Abbreviated Journal Support Care Cancer  
  Volume 25 Issue 12 Pages 3807-3814  
  Keywords Acupuncture Points; Acupuncture Therapy/*methods; Double-Blind Method; Fatigue/etiology/*therapy; Feasibility Studies; Female; Humans; Lung Neoplasms/pathology/*physiopathology/*therapy; Male; Middle Aged; Neoplasm Staging; Physical Therapy Modalities; Pilot Projects; Quality of Life; *Acupuncture; *Cancer-related fatigue; *Lung cancer; *Quality of life  
  Abstract BACKGROUND: Cancer-related fatigue (CRF) is a distressing symptom that is the most common unpleasant side effect experienced by lung cancer patients and is challenging for clinical care workers to manage. METHODS: We performed a randomized, double-blind, placebo-controlled pilot trial to evaluate the clinical effect of acupuncture on CRF in lung cancer patients. Twenty-eight patients presenting with CRF were randomly assigned to active acupuncture or placebo acupuncture groups to receive acupoint stimulation (LI-4, Ren-6, St-36, KI-3, and Sp-6) twice per week for 4 weeks, followed by 2 weeks of follow-up. The primary outcome was the change in intensity of CFR based on the Chinese version of the Brief Fatigue Inventory (BFI-C). As the secondary endpoint, the Functional Assessment of Cancer Therapy-Lung Cancer Subscale (FACT-LCS) was adopted to assess the influence of acupuncture on patients' quality of life (QOL). Adverse events and safety of treatments were monitored throughout the trial. RESULTS: Our pilot study demonstrated feasibility among patients with appropriate inclusion criteria and good compliance with acupuncture treatment. A significant reduction in the BFI-C score was observed at 2 weeks in the 14 participants who received active acupuncture compared with those receiving the placebo (P < 0.01). At week 6, symptoms further improved according to the BFI-C (P < 0.001) and the FACT-LCS (P = 0.002). There were no significant differences in the incidence of adverse events in either group (P > 0.05). CONCLUSION: Fatigue is a common symptom experienced by lung cancer patients. Acupuncture may be a safe and feasible optional method for adjunctive treatment in cancer palliative care, and appropriately powered trials are warranted to evaluate the effects of acupuncture.  
  Address Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong'An Road, Shanghai, 200032, China. isable624@163.com  
  Publisher
  Language English Number of Treatments  
  Treatment Follow-up Frequency Number of Participants  
  Time in Treatment Condition
  Disease Category OCSI Score  
  Notes PMID:28707168 Approved no  
  Call Number OCOM @ refbase @ Serial 2498  
Permanent link to this record
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